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NO dysfunction not only causes arterial contraction but also promotes smooth muscle proliferation, increases the adhesion of macrophages to endothelial cells, induces foam cell formation, and exacerbates platelet aggregation

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Unlike oral or injectable therapies, topical application provides targeted action where its needed most at the follicle

The main challenge, however, lies in modelling a disease as heterogeneous as PD, which can present cellular and molecular hallmarks differently between individuals, despite appearing similar among patients (Bloem et al., 2021)

Saarenhovi M, Salo P, Scheinin M et al (2017) The effect of an apple polyphenol extract rich in epicatechin and flavan-3-ol oligomers on brachial artery flow-mediated vasodilatory function in volunteers with elevated blood pressure