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Premature ovarian insufficiency: a toolkit for the primary care physician

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used the Foxp3YFP-Cre Gpx4FL/FL mouse model and found that GPX4-specific deletion in Tregs leads to lipid peroxide accumulation and triggers ferroptosis, accompanied by an increase in the proportion of Th17 cells and an enhanced anti-tumor immune response (151)

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They found that the deletion of a mitophagy protein, BNIP3, can reverse Mn-induced ROS generation

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Establishment of senescent chondrocytes The mouse embryonic carcinoma-derived chondrogenic cell line ATDC5 was used for in vitro studies

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doi: 10.1371/journal.pone.0152126 67

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