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All nicotine groups were exposed to cigarettes 2 h/day, 5 days/week, for 4 weeks, after which time rats received a daily oral gavage (OG) 45 min before cigarette exposure for 11 executive days, as follows: NIC groups received tris-base

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Thus, it is suggested that an insufficient supply of nutrients causes different consequences depending on the stage of pregnancy, at first causing changes in neuronal proliferation, and in the earlier stage causing changes in neuronal differentiation (46)