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doi: 10.1073/pnas.050004797 83 HoltzmanD

When the gut microbiota is disordered and the intestinal epithelial barrier is damaged, immune cells recognize a variety of bacterial components through pattern recognition receptors to recognize highly conservative pathogen-associated molecular patterns, leading to systemic and tissue-specific inflammation [345]

His legacy is therefore not tied to a single test or theory, but to a larger vision: that careful mechanistic science, applied to the most fundamental processes of biology, can illuminate the path to better health and longer life

For instance, NAC ingestion is proposed to result in an anti-oxidant effect that minimizes the oxidative stress and inflammatory response imposed from physical activity [151] (see Sect

doi: 10.1186/1742-2094-8-94 135 StrawnJ