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17 Using the FDA-recommended mechanistic static static model, mitragynine was predicted to have a negligible effect on the ratio of the area under the plasma concentration vs

PCFT , proton coupled folate transporter

As summarized in the same 2013 review, the pre-specified primary endpoint for statistically significant weight change across the dose range and study duration was not met, even as the safety and tolerability picture held [7]

Important: Every timeline below is extrapolated from animal studies and anecdotal community reports