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Conditions like inflammatory bowel disease (IBD) have been shown to decrease production (16)

10.1021/jf3025634 147 ShimonoM.SuganoS.NakayamaA.JiangC

However, investigation of the effect of UA on such models is limited by the profound differences between humans and e.g., rodents in UA metabolism, primarily due to the loss in humans of a functional uricase