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Similarly, the concomitant downregulation of Adam19, a metalloproteinase closely associated with inflammation and oxidative stress-induced tissue remodeling 56 , further reinforces the hypothesis that APP treatment actively promotes endogenous antioxidant defenses and improves redox homeostasis rather than provoking nonspecific oxidative damage

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Moreover, the rupture of the blood vessel wall in hemorrhagic stroke results in the accumulation of hemoglobin and heme iron at the extracellular milieu and subsequent iron-induced LPO and ferroptosis, thereby furtherly exacerbating the stroke-induced brain injury

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This guide covers its structure, regulation, disease roles and therapeutic targeting