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Endocrinology 140:53915401 Glowinski J, Kemel ML, Desban M, Gauchy C, Lavielle S, Chassaing G, Beaujouan JC, Tremblay L (1993) Distinct presynaptic control of dopamine release in striosomal- and matrix-enriched areas of the rat striatum by selective agonists of NK1, NK2 and NK3 tachykinin receptors

This isn't just an academic argument

The production of SAMe plummets, meaning the body can no longer efficiently synthesize the myelin needed to protect peripheral nerves, leading to tingling, numbness, and neuropathic pain

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While vitamin B12 deficiency can lead to the underdevelopment of the brain in early life, it can also lead to severe symptoms in adulthood, ranging from dementia, memory loss and cognitive/intellectual decline