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PMID: 18094238 Di Monte DA, Chan P, Sandy MS

The principal task at this time is to determine the risk of hepatocellular injury, and this involves two considerations: the time elapsed from the toxic ingestion, and the plasma level of acetaminophen

Conclusion: We have elucidated a new role of ERK5 in maintaining hepatocyte insulin sensitivity, via an antioxidant response involving IRS-1, PGC-1, and TRIB3, and converging on Akt activation

Students- t tests were used to determine the significance of differences between two groups and one-way analysis of variance and the Student-Newman-Keuls test were used to compare differences among multiple groups