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However, treatment with an AMPK inhibitor weakens this positive effect of sodium butyrate on mitophagy, highlighting the importance of sodium butyrate in maintaining mitophagy homeostasis ( An abundance of the microbial metabolite tryptophan has been observed in the gut of SLE patients and lupus-prone mice and is considered to shift the composition of the gut microbiome ( Mitochondria and lupus hematological damage Mitophagy mediates the elimination of organelles that are essential for regulating erythroid maturation

Western blot analysis (Fig

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10.1038/s41392-020-0149-3 13 ClarkeJ

The culture medium is changed every third day and the factors are also added at that time