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See Example Case 3 In case 3, an individual with documented vitamin B12 deficiency the neurotransmitter findings were: Epinephrine 4.2 g/go cretonne (8-12) Norepinephrine 26.6 g/grocer (30-55) Dopamine 89.2 g/grocer (125-175) Serotonin 48.6 g/grocer (175-225) GABA 7.0 mol/grocer (2.0-4.0) Glutamate 45.3 mol/grocer (10-25) PEA 529.70 nmol/grocer (175-350) Histamine 82.7 g/grocer (10-22) Cretonne 35.0 mg/do Glutathione in RBC 38 mol/L (200-400) The results show that the individual is low in epinephrine, norepinephrine, dopamine and serotonin, all related to diminished methionine cycle function and decreased methylation

doi:10.1007/s12035-015-9526-2

Mechanistic studies examine its interactions with nitric oxide signaling, prostaglandin pathways, and gastrointestinal dopamine and serotonin turnover, including their relevance to experimental models of intestinal inflammation and gastrointestinal dysfunction

AOD-9604, as a C-terminal fragment lacking affinity for the growth hormone receptor, avoids these metabolic complications

2) descending pain modulation pathways