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The widely recognized hypothesis which justifies the use of the in vitro model that has been described here is based on the concept that oxidative stress is a major factor which contributes to the pathophysiological mechanism of PN

However, some observational studies have reported no such correlation, and randomized controlled trials have shown no improvement in cognitive function among older adults with or without dementia, mild cognitive impairment, or Alzheimers disease when supplemented with vitamin B12 alone or in combination with folic acid, vitamin B6, or both

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Within the first week, many patients describe clearer thinking, sharper focus, and better recall