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5 Thymidylate Synthase inhibition specifically increases mitochondrial mass in an mTOR dependent manner

If you dosed 5-Amino-1MQ at 8am and it's now 3pm (7 hours), taking MOTS-c still provides some benefit but misses peak NNMT inhibition

Membranes, especially those with an abundance of negatively charged lipids, are able to catalyze hiAPP transformation into an -helical structure, especially in the presence of free copper, which then leads to membrane penetration and pore formation (Sitton et al., 2025)