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171 The succinate receptor (SUCNR1) is highly expressed on human mast cells, and pretreatment with succinate enhances IgEmediated human mast cell activation and antigeninduced airway contraction

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Nishikawa M, Kakemizu N, Ito T, Kudo M, Kaneko T, Suzuki M, Udaka N, Ikeda H, Okubo T (1999) Superoxide mediates cigarette smoke-induced infiltration of neutrophils into the airways through nuclear factor-kappaB activation and IL-8 mRNA expression in guinea pigs in vivo

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There's no established upper limit, and toxicity is extremely rare even at high doses