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In the second treatment period (14 days), 810 metabolites were up-regulated and 602 metabolites were down-regulated, taking the materials before treatment as the control ( Figure 4B ) and 734 up-regulated metabolites and 377 down-regulated metabolites were identified between the two stages of the Cd treatment ( Figure 4C )

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Doses of 2 to 4 times the therapeutic dose have only small effects, but the effect increases rapidly with doses above 8 times the normal therapeutic dose if P-450 activity is elevated