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Intriguingly, higher AIMP3 expression was associated with better survival in gastric and colon adenocarcinoma, but with poor survival in breast, lung, and liver cancers 101

As concern the first, the cathepsin-mediated cell death, our data are in line with those provided by other authors, demonstrating that inhibitors of autophagy, i.e., CQ and the phytochemical thymoquinone, could mediate lysosome permeability, resulting in leakage of cathepsin B into the cytosol where it can act as mediator of cell death 47

RhIGF-1 resulted in significant, sustained increases in GFR (4281%) over a treatment period of 45 days