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10.1093/neuonc/nou358 73 OuR.LuS.WangL.WangY.LvM.LiT.et al (2022)

The ICE-CBF-COR pathway in cold acclimation and AFPs in plants

Brain Res 1983;275:321-8

Initially, activated M1 microglia drive the inflammatory response by secreting pro-inflammatory cytokines, which contribute to extracellular matrix degradation, disruption of cell integrity, and damage to the BBB [43]

Furthermore, research indicates that CPS1, the key enzyme in the urea cycle, is predominantly expressed in hepatocytes and certain renal cells, with low or absent expression in most immune cells due to the urea cycles inactivity in these cells (134, 135)