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Nucleic Acids 28 , 387396 (2022)

doi: 10.1016/j.mehy.2023.111015 254

2 Till date, 10 anti-angiogenic agents have been approved by the US Food and Drug Administration: bevacizumab and ziv-aflibercept as anti-vascular endothelial growth factor (VEGF) agents, whereas sorafenib, sunitinib, pazopanib, axitinib, cabozantinib and regorafenib are approved as small-molecule RTK (receptor tyrosine kinase) inhibitors

Diet and exercise must be considered as the first line of treatment, however if they fail to correct metabolic signalling, IGF-1 therapy seems to be promising at metabolic harmonisation

J Endocrine Soc (2022) 6:bvab190