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Some minor toxicities like anemia, rash, fever, edema, etc., were found in 5.56% of the participants [263]

Furthermore, transcriptome investigations have demonstrated that berberine modulates the expression of genes associated with inflammation and glucose homeostasis

Green Synthesis of Multifunctional C-Dots Several researchers have recently involved in the development of C-Dots from a collection of green raw materials due to its great properties and environmental friendly synthesis routine as compared to toxic molecules in organic matter such as aromatic hydrocarbon compounds (Liu et al., 2014

A notable example is alprazolam, which has been shown to increase IL-1 secretion by macrophages, thereby increasing B- and T-cell activation [65]

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