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Tabata et al., 1999) are illustrative for the pertinence of the poorly resolved problem, illustrative for the diversity of the carriers (i.e., hyaluronate gel carrier (Wang and Aspengberg, 1996), alginate/heparinsacharose microspheres and films (Yu et al., 1998), cellulose gel (Thorn and Aspenberg, 1993), defective form of Pseudomonas exotoxin (Siegall et al., 1994), fibrin adhesive carrier (Walter et al., 1996), biodegredable hydrogen gelatin (Tabata et al., 1999), natural coral, and collagen (Damien et al., 1993))

Researchers modeling repeat-dose experiments generally aim to reach steady-state concentrations after four to five half-lives of continuous administration

& Brady, D

Molecular Life Sciences CMLS 62, 670684

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