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Approaches such as intranasal nose-to-brain delivery, receptor-mediated BBB transport, focused ultrasound-based BBB opening, and implantable hydrogel systems are being actively explored to improve access to brain tissue

10.1159/000496293 69 GottschalkG.PetersonD.KnoxK.MaynardM.WhelanR

Enter L-glutathione reduced, a potent antioxidant found in every cell, serving as a crucial line of defense against oxidative stress

If PIM1 regulates NRF2, and persister cancer cells are dependent on glutathione 4 peroxidase (GPX4) and methionine extra-supply (transsulfuration pathway), then PIM1 inhibition might serve as a relevant therapeutic strategy