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Rg1 can target and regulate Neurite outgrowth inhibitor-B (Nogo-B)/Ras homolog gene family member A (RhoA) signaling pathway, adjust the polarization ratio of M1 and M2 macrophages, promote upregulation of NLRP12 expression, and suppresses IL-1 and TNF- through TLR4 signaling pathway, further restoring the balance of anti-inflammatory and pro-inflammatory factors (Zhu et al., 2017

The BBB is composed of capillary endothelial cells, an intact basement membrane, and glial membranes surrounding astrocyte foot plates and is a barrier between the walls of brain capillaries and plasma to brain cells formed by glial cells

these genes are conserved in all Ajellomycetaceae included in this analysis (Table S6)

3.2.1 Caloric restriction Caloric restriction (CR) is the most robust and the best studied dietary intervention for its effect on promoting longevity