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Aging Aging is accompanied by the progressive loss of anatomical structure and physiological function of the body (organs, tissues, and cells) leading to age-related diseases such as cardiovascular (atherosclerosis, stroke, etc.), musculoskeletal (sarcopenia and osteoporosis), neurodegenerative (dementia, etc.), immunological (arthritis, inflammaging and metainflammation), endocrine/metabolism diseases (diet, obesity and insulin resistance, etc.), gastrointestinal disorders (irritable bowel, celiac disease, etc.), and various cancers

Grivennikova VG, Vinogradov AD

SREBP-1c down-regulates the activity of fatty acid synthesis genes, consequently leading to a diminished mitochondrial fatty acid oxidation

Higher levels of soluble A42 in cerebrospinal fluid (CSF) is associated with better neuropsychological function and increased volume in the hippocampus [188]

An amalgamation of metabolic and immune findings revealed that certain molecular features, including IL-6, IL1-ra, DMG, CCL4, IIe, Gly, and IL-8, offer diagnostic precision in differentiating newly diagnosed psoriasis patients from healthy individuals (114)