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Found in nearly every cell, this antioxidant is central to detoxification, cellular repair, and immune balance. Yet, its bioavailability in traditional supplements is limited due to breakdown in the digestive tract

9 , e1003123 (2013)

Taken together, all results observed in mentioned studies indicate a new underlying mechanism of mechanical overloading to the progression of OA, that is, the GPX4-associated ferroptosis pathway (Fig

Broadly, at the genetic level ferroptosis is likely to involve genetic changes in iron homeostasis and lipid peroxidation metabolism

HO-1-mediated production of CO, BV, and BR may reduce cellular damage by counteracting oxidative stress and inflammation