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These receptors, including the 5HT 1A , 5HT 3A , TRP channels, D2 dopamine receptors, K V 7.2, K V 7.3, Na V 1.11.7, and L-type and T-type calcium channels, may have synergistic or oppositional effects upon CBD binding

Methods : Studies were double abstracted by trained researchers

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The guidelines on risk assessment of neurotoxic agents also clearly indicate that an uncertainty factor of ten should be applied to address inter-individual variability in susceptibility to the toxic effects of neurotoxins such as mercury vapor