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Patients with autistic spectrum disorders (ASDs) exhibit higher proportions of mitochondrial dysfunctions than the general population (Rossignol and Frye, 2012), as evidenced by developmental regression, seizures, and elevated serum levels of lactate or pyruvate in ASD patients

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Limitations of human biomonitoring and objectives HBM relies not only on validated analytical tools, but also on a clear understanding of the relationship between exposure to a toxin and concentration of that toxin (or metabolite) in a biological sample

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