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Isoniazid (INH), a tuberculosis medication, and hydralazine, used for hypertension, both form complexes with pyridoxal 5-phosphate or otherwise interfere with vitamin B metabolism, leading to functional vitamin B deficiency

However, species-specific differences (for example, in metabolism and toxicity) impact understanding of which concepts are universal and which are species-specific, making the translation of potential therapeutic targets into effective human therapies a substantial challenge

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Some investigators found a compensatory increase of other vitamin B 6 derivatives in maternal circulation corresponding to the fall of PLP (Reference Barnard, de Kock and Vermaak61) and unchanged urinary excretion of the catabolic product 4-pyridoxic acid (Reference Trumbo and Wang60) leading to the conclusion that there are no substantial changes in vitamin B 6 status in pregnancy, however, this remains uncertain as others have failed to confirm these findings (Reference Shane and Contractor62)

Other components of the injection aid in fat metabolism and detoxification