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Additionally, SIN influences the nuclear factor erythroid 2-related factor 2 (Nrf2)/ heme oxygenase-1 (HO-1) pathway, leading to the suppression of NF-B activity in mouse chondrocytes, thereby curbing inflammatory reactions and the breakdown of extracellular matrix elements

22(1):5374 The somatomedin hypothesis and insulin-like growth factor signaling in endocrine regulation Yakar S, Liu JL, Stannard B, Butler A, Accili D, Sauer B, Le Roith D., Journal of Clinical Investigation , 2001