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Otherwise, there is the milder increases of the pressure in the ligated superior sagittal sinus upon additional volume application in the right external jugular vein or in the inferior caval vein, where in the control rats, the portal/caval hypertension remained unchanged, but contributed to the further raise of the increased pressure in the superior sagittal sinus (Figure 5)

The central mechanism is angiogenesis: the peptide upregulates vascular endothelial growth factor (VEGF) and drives new blood-vessel formation at injury sites, which brings oxygen and nutrients to healing tissue

Utiger, R

I hope more research is done in the future in this area to answer this question

Its best to stick to a regular schedule with B12 shots