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Plasma steroid concentrations in male rhesus monkeys following treatment with the P450c17 (CYP17) inhibitors VT-464 and abiraterone acetate: a comparison to human 17,20-Lyase (lyase) and combined lyase/17-hydroxylase (hydroxylase) deficiencies [abstract]

Fecal microbiota transplant improves cognition in hepatic encephalopathy and its effect varies by donor and recipient

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Subsequently, caspase-1 is activated, which in turn cleaves Gasdermin D (GSDMD), leading to cell membrane perforation and release of interleukin-18 (IL-18) and IL-1, ultimately resulting in cell swelling and pyroptosis (Liu et al., 2024)