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Multiple randomised trials from the 1970s and 1980s have shown its antiparkinsonian efficacy while its antidyskinetic efficacy in PD patients with LIDs was only demonstrated some 30 years after its introduction into PD therapy [13]

An example of an NO prodrug is O 2 -(2,4-dinitrophenyl)1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate (JS-K), devised by Keefer et al from the National Cancer Institute

SachsUJAndrei-SelmerCLManiarAWeissTPaddockCOrlovaVVet alThe neutrophil-specific antigen CD177 is a counter-receptor for platelet endothelial cell adhesion molecule-1 (CD31)

Alimentary Pharmacology and Therapeutics 38, 255263