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Many arginase inhibitors with high affinity have been developed over the past several decades, such as N-hydroxy-L-arginine [NOHA, K i = 3.6 M for human ARG1 (Di Costanzo et al., 2010), 1.6 M for human ARG2 (Colleluori and Ash, 2001)], N-hydroxy-nor-L-arginine [nor-NOHA, K d = 0.47 M for human ARG1 (Di Costanzo et al., 2010), 51 nM for human ARG2 (Colleluori and Ash, 2001)] and boronic acid derivatives like 2(S)-amino-6-hexanoic acid (ABH) [IC 50 values of derivatives range 171,470 nM for human ARG1, 302,150 nM for human ARG2 (Collet et al., 2000

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Think of antioxidants as a broom that comes in to sweep up any debris in our bodies