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Activity-dependent, stress-responsive BDNF signaling and the quest for optimal brain health and resilience throughout the lifespan

Genetically, ferroptosis is controlled by genes in multiple pathways (Xie et al., 2016

You stand in an open-topped cylindrical chamber that surrounds your body in a fog of liquid nitrogen chilled to an arctic minus 240 degrees

Rhodes et al., 2022) ( Supplementary File 1 )

Interestingly, DHODH and GPX4 constitute two primary defenses to detoxify lipid peroxidation in the mitochondria, and inhibiting one pathway can enforce cell more partial to the other one, whereas inactivation of both can lead to ferroptosis triggered by mitochondrial lipid peroxidation (Mao et al., 2021)