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It is believed that PIs enhance the therapeutic efficacy of Daratumumab by sensitizing tumor cells for NK-mediated ADCC and improving MM cell lysis

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Healthy cells dynamically recruit chaperones, activate stress responses, mobilize UPS function, and initiate autophagy and mitophagy as integrated responses to stress

Delphinidin targets the Nuclear Factor-kappa B (NF-B) pathway by downregulating IKK, thereby inhibiting IB phosphorylation and NF-B p65 nuclear translocation, leading to G2/M cell cycle arrest (Yun et al., 2009

In animal models of heart failure induced by high-frequency pacing, ischaemia, and obesity, GLP-1RAs inhibit left ventricular remodelling and improve left ventricular contractility and diastolic function through anti-inflammatory effects, cardiomyocyte apoptosis inhibition, and glucose metabolism enhancement in cardiomyocytes [38,39,40]