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For othersparticularly those with severe B12 deficiency or symptoms that have been present for a long timeit might take several days to a few weeks to experience noticeable improvement

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When You Might Need Higher B12 Doses While the standard RNI of 1.5 mcg per day suffices for most healthy adults, certain medical conditions, dietary patterns, and medications can substantially increase B12 requirements or impair absorption, necessitating higher therapeutic doses under medical supervision