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Step 3: Support with precursors

Human leukocytes, including peripheral blood mononuclear cells (PBMCs) and polymorphonuclear leukocytes (PMNs), were isolated from the blood of healthy donors using Histopaque (Sigma-Aldrich, USA)

One of these enzymes, HNMT, needs SAM to do its job.2 So, for HNMT to break down histamine properly, its important that the MTHFR enzyme is working well to support this process