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Notably, NADPH depletion sensitizes fibrosarcoma HT-1080 cells to ferroptosis inducers, indicating that NADPH is negatively associated with ferroptosis sensitivity (48)

doi: 10.1007/s40610-020-00140-1

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It promotes: amino acid uptake ribosomal protein production muscle fibre hypertrophy IGF-1 also activates satellite cells, which are muscle stem cells

Unexpectedly, this was attributed to a non-canonical transaminase pathway, independent from canonical -KG-dependent immunometabolism (Merlin et al., 2021)