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Among those 22 protein complexes, we selected four, encompassing 11 of the 39 enzyme targets, for further experimental validation based upon additional criteria such as evidence from CRISPR-Cas9 screens 32,33,34 , relevance in other viral diseases, and the availability of inhibitors, as discussed below

Furthermore, massive migration of classical monocytes to inflamed tissues could prevent these cells to differentiate into the non-classical monocytes, which may partially explain their disappearance from the peripheral blood observed in COVID-19 and many other inflammatory diseases

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GLS1 is a particularly appealing target in light of the introduction of multiple smallmolecule allosteric inhibitors [312]

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