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Its role in preserving NAD+ and supporting mitochondrial health led to its use in advanced clinical longevity protocols as a tool to help protect NAD+

NAD+ Preservation and Sirtuin Activation First and most directly, NNMT activity consumes nicotinamide, which is a key precursor for NAD+ biosynthesis through the salvage pathway (the predominant NAD+ synthesis route in most mammalian cells)

Fat-soluble vitamins: updated review of their role and orchestration in human nutrition throughout life cycle with sex differences