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Response: We acknowledge commenter's concern about outdated data and collection periods that do not always align across measures

Furthermore, the presence of AHK-Cu may reduce the number of apoptotic DPCs, potentially increasing the Bcl-2/Bax ratio and lowering the levels of cleaved caspase-3 and PARP, two markers of cell death[2]

Patients should also be aware that certain medicationssuch as proton pump inhibitors (PPIs) and metformincan interfere with B12 absorption, though this is less relevant once on injection therapy