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Int J Mol Sci 22(11):5887

Around 25-40 days after the immunization, approximately 50% of mice develop a second wave of paralysis (relapse)

In addition to the well-known PF-PC LTD, GABAergic synapses on PCs undergo long-lasting synaptic modifications

Combined application of AAV-shGSTP1 did not significantly affect the expression of SIRT5 but significantly inhibited the expression of GSTP1 and elevated pyroptosis- and ECM-related proteins

Importantly, at early passages, we can identify a subpopulation of cells with the astrocyte-like phenotype by scRNA-seq, however, this population is eventually selected out or transformed at later passages (Fig