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232 The deletion of S6K1 in mouse embryonic fibroblasts enhances mitochondrial fission by increasing both total DRP1 and its S616-phosphorylated form (not a target of S6K1 but a substrate of PINK1, CDK1 and other kinases), which in turn stimulates glycolysis

The most recent demonstration of the use of the CLipPA methodology from the Brimble group was in the synthesis of truncated S -lipidated teixobactin analogs (Yim et al., N -terminal of truncated teixobactin with 3-mercaptopropionic acid provided the thiol handle for CLipPA

Cao ZZ, Qin ML, Lin XY, Zhu ZW, Chen MX (2018) Sulfur supply reduces cadmium uptake and translocation in rice grains (Oryza sativa, L.) by enhancing iron plaque formation, cadmium chelation and vacuolar sequestration

While challenges persist in identifying unknown secondary metabolites, the evolving strategies for HRMS data collection and analysis provide optimism for unearthing therapeutic leads in the future (Peisl et al., 2018)

[DOI] [PubMed] [Google Scholar] [134].Scheppach W, Bartram P, Richter A, Richter F, Liepold H, Dusel G, et al