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In CVD, PEV fusion with mesenchymal stem cells may exert cardioprotection through immunomodulation and anti-inflammatory effects [86,87,88] (Fig

[DOI] [PMC free article] [PubMed] [Google Scholar] 202.Ingold I., Berndt C., Schmitt S., Doll S., Poschmann G., Buday K., Roveri A., Peng X., Porto Freitas F., Seibt T., et al

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However, significant challenges remain, including the synthesis of stable tripeptides with good tissue penetration, insufficient understanding of their mechanisms of action, the scarcity of studies in larger animal models and human trials, and the lack of direct head-to-head comparisons with larger peptides [75, 95]

Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor