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Briefly, mutant strains were cultivated in 5 mL MOPS minimal medium with appropriate antibiotics at 37 C without or with supplementation of 5 mM GSH or GSSG for around 18 h

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Its gastric origin contributes to its unusual stability in acidic conditions

Then they found that metformin Encapsulated PDANPs promotes EZH2-mediated ubiquitination of -SYN at PSer129, triggering the ubiquitin-proteasome degradation pathway of -SYN, enhancing the neuroprotective effect of metformin and providing a new idea for optimization of metformin (Sardoiwala et al., 2020)

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