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2301-C E3 UBIQUITIN LIGASE NEDD4 IS A KEY NEGATIVE REGULATOR FOR GSDMD-MEDIATED PYROPTOSIS IN NON-ALCOHOLIC STEATOSIS Rui Jin, Xiaoxiao Wang, Baiyi Liu, Zilong Wang, Yuyun Song, Xiaohe Li, Feng Liu and Huiying Rao, Peking University People's Hospital, Peking University Hepatology Institute, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Beijing International Cooperation Base for Science and Technology on NAFLD Diagnosis Background: Pyroptosis mediated by GSDMD is thought to be involved in NASH development, but the roles of GSDMD in the pathogenesis of NASH are not fully understood

As Yaribeygi, Journal of Cellular Physiology emphasized, while mitochondrial peptides hold therapeutic promise, their systemic effects require caution due to the lack of long-term human studies

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