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How SNRIs Work: A Pharmacology Refresher Venlafaxine and duloxetine inhibit the reuptake of both serotonin (5-HT) and norepinephrine (NE) at presynaptic transporters

Seiwerth S et al

Considering these data, it has been suggested that IC/BPS is a member of a family of hypersensitivity disorders which affects the bladder and other somatic/visceral organs, and has many overlapping symptoms and pathophysiology