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The accumulation of protein aggregates and damaged organelles due to defective autophagy contributes to neuronal dysfunction and degeneration

[87] Li Y, Wang Z, Kong D, et al

By significantly reducing stomach acid, PPIs create an environment where bacteria that are normally kept in check can proliferate in the small intestine

Jedoch sind diese Erkrankungen nicht die Folge eines Mangels, sondern oftmals der Auslser

The peroxisome proliferation-activated receptor is a nuclear transcription factor acting as a vital task in the mechanism of NSAID action, controlling nuclear factor (NF)-B, vascular cell adhesion molecule-1, endothelin-1, in endothelial cells, matrix metalloproteinase-3, TNF- and other transcription factors [31, 74, 83]