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The principal mode of regulation is through high-affinity glutamate transporters, which efficiently remove glutamate from the perisynaptic and extrasynaptic spaces (Danbolt, 2001)

MacVicar BA, Newman EA (2015) Astrocyte regulation of blood flow in the brain

doi: 10.1207/S15327914NC4502_06

It stabilizes the active conformation of the receptor, allowing for the recruitment of the co-activator PGC-1

Mechanism of Action Pancreas: Increases glucose-dependent insulin secretion, decreases glucagon Brain: Enhances satiety Stomach: Slows gastric emptying Main Indications Type 2 diabetes mellitus Obesity/weight management Cardiovascular risk reduction Common Drugs Exenatide Liraglutide Semaglutide Dulaglutide Tirzepatide (dual GIP/GLP-1 agonist) Key Benefits Significant weight loss Low hypoglycemia risk Cardiovascular protection Major Side Effects Nausea/vomiting (most common) Pancreatitis (rare) Thyroid C-cell tumors (boxed warning) Contraindications Multiple Endocrine Neoplasia type 2 (MEN2) Personal/family history of medullary thyroid carcinoma #Pharmaceuticals #GLP1 #Diabetes #Obesity #Healthcare #Biotech #ClinicalResearch #Endocrinology #MedicalAffairs To view or add a comment, sign in Blockbuster weight loss drugs like Ozempic deliver big results but face big questions Three recently released Cochrane reviews conclude that GLP-1 medications, such as Ozempic, can lead to meaningful weight loss