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Most, if not all of these actions are mediated by the IGF-1 receptor, and they are strongly modulated by IGF binding proteins

Expression of growth hormone secretagogue-receptors by growth hormone-releasing hormone neurons in the mediobasal hypothalamus

Transfected HEK293T cells were treated in triplicate for 4 hours with a serial dilution of IGF-1 which had been pre-incubated in conditioned media for 7 days