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Indeed, in several studies it has been proposed that GST polymorphisms may be used as biomarkers for prognosis in cancer patients 39,45

In the chimeric tyrosine kinase (3T3 EN) transformed 3T3 KRAS V12 cell line [54, 55], and under exogenous oxidative stress conditions when tracking SLC7A11 expression using the system Xc- tracer (18)F-5-fluoroaminosuberic acid ((18)F-FASu) [56, 57], it was found that the expression and activity of SLC7A11 appeared upregulated in the 3T3 KRAS V12 cell line compared to the normal cell line [58]